Endocrine Abstracts

A 23-year-old female presented with a three-month history of palpitations, tremors and recent anxiety. This was associated with hot flushes in the morning, heat intolerance and increase in appetite. Otherwise, bowel habits were normal and the patient suffered from long-standing menorrhagia with regular menstrual cycles. She denied a recent viral illness, neck pain or swelling, dysphagia, shortness of breath or dysphonia. She denied thyroid eye disease symptoms. She denied a pa...

A 57-year-old gentleman presented with severe hypercalcaemia (Corrected Calcium 3.48 mmol/l) associated with polyuria and polydipsia. He denied pruritus, nausea, vomiting, abdominal pain, constipation or other aches and pains. He denied syncope, seizures, haematuria or recent urinary tract infections. He had a past history of bilateral urolithiasis as well as right pyelonephritis and hydronephrosis requiring nephrostomy, Crohn’s Disease and Diverticular Disease. Drug Hist...

Background: Immune checkpoint inhibitors (ICPis) have become a cornerstone of cancer management. Whilst endocrine-related adverse effects are one of the most common immune-related adverse events, ICPi-induced de novo diabetes occurs at low frequencies1. We describe a case of ICPi-induced de novo type 1 diabetes presenting with severe diabetic ketoacidosis (DKA) in a female with metastatic melanoma.Case report: A 50-year-old l...

Background: Thyrotoxicosis is a well-known complication of amiodarone therapy. Three types of amiodarone-induced thyrotoxicosis (AIT) are recognized; type 1 AIT, type 2 AIT, and mixed/indefinite forms of AIT. Type 1 AIT is an iodine-induced hyperthyroidism that usually occurs in patients with pre-existing nodular goitre or latent Graves’ disease1. We present a case of type 1 AIT associated with a transiently toxic solitary thyroid nodule, with hyperthyroidism r...